Abnl (low) 24hr Urine VMA w/metanephrines - Question and Answer Forum - Elaine Moore Graves' Disease and Autoimmune Disease Education

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Wednesday, February 08, 2012

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Abnl (low) 24hr Urine VMA w/metanephrines

6/26/2010 12:55 PM

Robin

Joined: 6/26/2010

Posts: 1

Abnl (low) 24hr Urine VMA w/metanephrines

Hello Elaine,

I was wondering if you could help guide me to what condition(s) may cause my 24hr urine VMA w/metanephrines results to be low? My results were 23 for the normetanephrines (reference range 110-1050) and 6 for the metanephrines (reference range 35-460). My doctor performed this test as a long shot for pheochromocytoma because I've had 4 ER visits in the past 6 months for sudden onset of tachycardia, headache, dizziness, nausea/vomiting, arm pain, chest tightness, elevated BP and then finally, extreme fatigue after the episodes. The ER always dismisses me as having had a panic attack, but the amazing thing is, these "attacks" wake me up from sleep and are not something I have when I'm awake. \

Of note, I'm a 43 yo female with a history of asthma and PCOS and I'm scheduled for surgery to remove a complex cyst on my ovary in 2 weeks. My complete cardiac work-up, MRA and CT of the brain were all normal.

Would you please offer any suggestions you may have as to the cause of the low test results and any diagnostic tests you think I should request from my PCP?

Thank you so very much.

Kindest Regards,

Robin

6/28/2010 11:39 AM

Elaine

Joined: 8/1/2008

Posts: 3174

Re: Abnl (low) 24hr Urine VMA w/metanephrines

Hi,

All my reference books list causes for elevated results but none for low results. Low results can result from specimen collections that are over-dilute on occasion. You doctor might run some other adrenal function tests to see if there are indications of adrenal insufficiency. Best, Elaine

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Abnl (low) 24hr Urine VMA w/metanephrines

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