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THE Q & A

Welcome to The Q&A with Elaine Moore. Registered members are invited to ask any question of Elaine Moore on autoimmune diseases, Graves' disease, other thyroid diseases and subconditions, laboratory work, traditional and complementary medicine, triggers and environmental influences, thyroid and immune disorders in pets and animals, and other relevant areas of inquiry.

Each thread represents one question with one answer and will only appear at the time it is answered. Once answered, further replies cannot be made to the same thread since each thread represents only one question. A new thread will need to be started for additional questions.

Questions are answered solely by Elaine Moore, a medical writer and clinical laboratory scientist, MT, CLS, with more than 30 years of experience in immunology. Moore has also authored and edited over a dozen books in the area of health sciences and is an editor for McFarland Publisher's Health Topics Series.


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 7/12/2010 5:24 AM
 

Dear Elaine,
Thank you for your replies and help. I was able to secure a part of your book on Thyroid Eye Disease and would like to seek clarifications on the ff:
  1. "Eye muscle surgery to correct diplopia can best be performed when GO is on the active phase when muscle is inflamed." Why is this so? Is it not that when you wait till you are in the resolution or plateau phase of GO that the muscle might return to its original conditions and if there are still signs of diplopia it is best to correct same in plateau stage? And what are the chances that the muscle affected by GO be back to its original conditions?
  2. You mentioned that GO run its own independent course vis a vis GD, while one s TSH and FT4 must be in their normal ranges during this period or one should be a euro thyroid or in GD remission for GO to be corrected. My question is when do you start the count of the months to wait for the GO to subside? when one starts on remission? or when one starts to have his thyroid hormones in normal range or be in euthyroid?
  3. What other lab test do you do to determine if your GO is still in the active phase (other than TSI and antibody count, which are not done here in our area). What physical conditions should one observe to determine if your GO is in the active, resolution or plateau phase
  4. I might be able to travel to the US next year. Can you please refer some ORTHOPTISTS or medical institutions that can help me in the areas of Texas or NY. I donot have medical insurance.
Thanks and regards,
TILUSBOB
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 7/13/2010 12:12 AM
 

Hi Tilusbob,

Diplopia occurs when the eye muscle sort of gets stuck in position and can't rotate the way it should. Crowding of the orbital cavity resulting from inflammation cause it to occur. Surgery for severe diplopia can help prevent permanent scarring or fibrosis, but still it's not usually needed. Usually, diplopia can be manged with special lenses and eye exercises can help keep the muscle mobile.

Autoimmune GO does run its own course independent of the eye disease. In general, TSH will remain low since it's falsely lowered by TSH receptor antibodies and they're typically high (both stimulating and blocking antibodies) in people with TED. In TED related to low or high thyroid hormone levels, symptoms improve when thryoid hormone levels are corrected and brought into the reference range. Once autoimmune GO develops, the active phase can last anywhere from several months to 5 years, although for most people the active phase runs for about 18 months. Smoking worsens TED and smokers usually have longer disease courses.

Your ophthalmologist is able to assess if your eyes are still showing signs of active inflammation. Often, MRI is used to evaluate TED and some doctors use eye measurements. In most cases of TED, surgery isn't needed and symptoms resolve on their own. Most of the ophthalmologist I've met have retired but if you venture to the states and are headed for a particular city, I'll check my connections. Best, Elaine

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