You are here:   Blog
Register   |  Login

The Wellness Blog with Elaine Moore

Elaine Moore's Blog
Elaine Moore
260 5742 8/18/2014

To read the entire blog, click on:
Read More>>


Categories

Main Blog

 
     

Psychiatric Component of Graves' Disease

By Elaine Moore on 6/28/2012

A study of the medical literature indicates that mental symptoms are a common symptom in Graves' disease. According to the authors of the study,

"Antithyroid drugs combined with beta-adrenoreceptor antagonists are the treatment of choice for hyperthyroidism, as well as for the psychiatric disorders and mental symptoms caused by hyperthyroidisim. A substantial proportion of patients have an altered mental state even after successful treatment of hyperthyroidism, suggesting that mechanisms other than hyperthyroidism, including the Graves' autoimmune process per se and ophthalmopathy, may also be involved. When psychiatric disorders remain after the restoration of euthyroidism and after treatment with beta-adrenoreceptor antagonists, specific treatment for the psychiatric symptoms, especially psychotropic drugs, may be needed."  Unfortunately, the question of whether these patients might be hypothyroid rather than hyperthyroid isn't addressed and the only parameter reviewed is the TSH.

Early on, the physician Robert Graves described Graves' disease as being associated with symptoms of exhaustion psychoses and delirium. With patients being diagnosed earlier and the effectiveness of anti-thyroid drugs, these symptoms are no longer common. Other mental symptoms, such as moodiness and irritability, are, and they too respond well to corrected thyroid hormone levels.

Although this study is fairly recent (2006) it doesn't address the fact that euthyroidism is (although technically it shouldn't be) based on the TSH level and the fact that after remission or agressive treatment, hypothyroidism is common. Mental symptoms, particularly depression and bipolar and unipolar episodes, are commonly seen in untreated and under-treated hypothyroidism. A low TSH, according to this study, is likely to be associated with mental symptoms, but there is no correlation with thyroid hormone levels or the fact that the patient may be hypothyroid and still have a low TSH. This seems to another connection or possible reason for persistent symptoms in patients deemed "euthyroid."

Source;

Buevicius, Robertas and Arthur Prange, "Psychiatric Manifestations of Graves' Hyperthyroidism," Central Nervous System Drugs, 2006: 20(11): 897-909.

 

Graves' Disease
mental symptoms
psychiatric

ELAINE-MOORE.COM

Elaine Moore Graves’ Disease and Autoimmune Disease Education
This site copyrighted © by Elaine Moore. All Rights Reserved
Last updated: March 11, 2014

 

The pages and their content, including all articles and images, are copyrighted and are not to be copied, reproduced or printed without written permission. This site is self-funded exclusively by Elaine Moore. Moore has no other external sources of funds and receives no monies from government agencies, pharmaceutical companies or other commercial entities to operate this site. There are no conflicts of interest in the operation of this site. Books by Elaine Moore are promoted in the Books section. This site complies with the HONcode standard for trustworthy health information. Disclaimer: The information at this site about the benefits or performance of any diagnostic or treatment is supported by scientific evidence such as medical journals, reports, articles, and other relevant materials. The educational information provided within is designed to help users better understand the nature of disease and the solutions available. Nothing contained on this website should be construed as or is intended to be used for medical diagnosis or treatment. It is recommended that a physician be consulted for diagnostic testing and treatment. Reference to any specific commercial or noncommercial products, services, processes, companies or trademarks does not constitute an endorsement or recommendation. Elaine Moore does not host any form of commercial advertisement or sponsor or endorse any products or services mentioned at the site, excluding her own copyrighted materials, articles, and books. The opinions, views, and recommendations of those registered to this site, are their own and do not represent those of Elaine Moore.